JPAC Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee

17.2: Nomenclature

The current nomenclature for HNA and corresponding antibodies is based on epitopes and allelic typing and this must be used for recording granulocyte-specific alloantigen and alloantibody specificities1 (see Table 17.1).

Table 17.1 Current nomenclature for HNA alleles, epitopes and corresponding antibodies

System Allele Epitopes Original name Glycoprotein CD

HNA-1

FCGR3B*01

HNA-1a

NA1

FcγRIIIb

CD16

FCGR3B*02

HNA-1b, HNA-1d

NA2

FcγRIIIb

CD16

FCGR3B*03

HNA-1b, HNA-1c

SH

FcγRIIIb

CD16

FCGR3B*04

HNA-1a

 

FcγRIIIb

CD16

FCGR3B*05

HNA-1bv

 

FcγRIIIb

CD16

HNA-2

Unknown

HNA-2

NB1

GP56-64kDa

CD177

HNA-3

SLC44A2*01

HNA-3a

5b

CTL-2

 

SLC44A2*02

HNA-3b

5a

CTL-2

 

SLC44A2*03

HNA-3av

 

CTL-2

 

HNA-4

ITGAM*01

HNA-4a

MARTa

CD11/18

CD11b

ITGAM*02

HNA-4bw

 

CD11/18

CD11b

HNA-5

ITGAL*01

HNA-5a

ONDa

CD11/18

CD11a

ITGAL*01

HNA-5bw

 

CD11/18

CD11a

v: indicates a variant epitope that may have different serological characteristics with some antisera.
w: indicates a workshop designation – no antibodies against this epitope have currently been described.

 

Last updated 04/09/2023